Major Program
Supportive Care and Symptom Management
NCI Community Oncology Research Program
Research Group
Community Oncology and Prevention Trials
Sponsor
University of Rochester NCORP Research Base
Status
Recruiting
NCT ID
NCT05838716
This phase III trial tests whether high-dose vitamin D works in treating androgen-deprivation therapy (ADT)-induced bone loss in patients with prostate cancer who are undergoing androgen-deprivation therapy. Vitamins are substances that the body needs to grow and develop normally. Vitamin D helps the body absorb calcium. Calcium is one of the main building blocks of bone. A lack of vitamin D can lead to bone diseases such as osteoporosis or rickets. This trial may help researchers determine if high-dose vitamin D helps keep bones strong, lowers number of falls, and lessens fatigue in men getting androgen-deprivation therapy.
Intervention
Biospecimen Collection, D Vitamin, Dual X-ray Absorptiometry, Placebo Administration, Quality-of-Life Assessment, Questionnaire Administration
Condition
Stage I Prostate Cancer AJCC v8, Stage II Prostate Cancer AJCC v8, Stage III Prostate Cancer AJCC v8, Stage IVA Prostate Cancer AJCC v8
Investigators
Luke J Peppone, PhD, Sarah E. Jax, Rajasree P. Chowdry, Michael Humeniuk, Gregory A. Masters, Stephen H. Dyar, Khawaja S. Jahangir, Elizabeth M. Wulff-Burchfield, Brian T. Halbert, Asit K. Paul, Heath B. Mackley, Brian L. Burnette, Elie B. Choufani, Site Public Contact, Asheesh Shipstone, Seth M. Miller, William J. Irvin, Jay W. Carlson, Vamsi K. Vasireddy, Bryan A. Faller
CT Research Area
Symptom Science