Major Program
Supportive Care and Symptom Management
NCI Community Oncology Research Program
Research Group
Community Oncology and Prevention Trials
Sponsor
Children's Oncology Group
Status
Recruiting
NCT ID
NCT06513962
This phase III trial compares the effect of giving triptorelin vs no triptorelin in preventing ovarian damage in adolescents and young adults (AYAs) with cancer receiving chemotherapy with an alkylating agents. Alkylating agents are part of standard chemotherapy, but may cause damage to the ovaries. If the ovaries are not working well or completely shut down, then it will be difficult or impossible to get pregnant in the future. Triptorelin works by blocking certain hormones and causing the ovaries to slow down or pause normal activity. The triptorelin used in this study stays active in the body for 24 weeks or about 6 months after a dose is given. After triptorelin is cleared from the body, the ovaries resume normal activities. Adding triptorelin before the start of chemotherapy treatment may reduce the chances of damage to the ovaries.
Intervention
Best Practice, Biospecimen Collection, Electronic Health Record Review, Survey Administration, Triptorelin Pamoate
Condition
Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
Investigators
Eric J Chow, Site Public Contact, Iftikhar Hanif, Florence Choo, Matthew D. Ramirez, Jill C. Beck, David L. Becton, Amanda Saraf, Lauren R. Weintraub, Aarati V. Rao, Emad K. Salman, Alice Lee, Jean M. Tersak, Bradley DeNardo, Vibhuti Agarwal, Laura E. Hogan, Julie Voeller, Ksenya Shliakhtsitsava, Kathleen Y. Butler, Judy L. Felgenhauer, Michael J. Ferguson, Jay W. Carlson, Catherine A. Long, Jessica M. Sun, Jessica M. Valdez, Ashley M. Jean, Maria T. Grosse-Perdekamp, Matteo M. Trucco, Kari Bjornard, Xiaxin Li, Dipti S. Dighe, David S. Dickens, Brian A. Van Tine, Erin Wright, Mark A. Ranalli, Michael S. Isakoff, Erwood G. Edwards, William D. Roberts, Sarah Supples, Susan J. Lindemulder, Jenna M. Demedis, Kerri Becktell, Don E. Eslin, Rusha Bhandari, Jennifer L. Reichek, Lillian R. Meacham, Karim T. Sadak, Maurizio L. Ghisoli, Rafi R. Kazi, Karen H. Albritton, Ramez N. Eskander, Brian Stover, Najat C. Daw, Jamie M. Aye, Jordan M. Wright, Elizabeth J. Davis, Keith J. August, Stephanie Fetzko, Jill P. Ginsberg, Burton E. Appel, Melissa A. Forouhar, Gregory P. Brandt, Betty L. Herrington, Clinton M. Carroll, Benjamin Carcamo, Samantha L. Mallory, Craig Lotterman, Gregory A. Masters, Doured Daghistani, Sarah E. Leary, Wade T. Kyono, Albert Kheradpour, Allen I. Stering, Rebecca E. McFall, Maria C. Velez-Yanguas, Noah C. Federman, Sandra Baril
CT Research Area
Symptom Science