Georgetown University
United States
National Capital Area (NCA) NCI Community Oncology Research Program (NCORP)
The NCA NCORP (funding support from 5UG1CA239758-06) is based at Georgetown Lombardi Comprehensive Cancer Center (LCCC), and consists of Medstar Georgetown University Hospital (MGUH) and MedStar Washington Hospital Center (MWHC) as the primary affiliate, with a catchment area comprising 58.9% understudied populations within Washington, D.C. and adjacent counties in Maryland and Virginia. Cancer burden is greatest among representative populations in our catchment area as evident by some of the highest mortality rates in the nation for breast, prostate, and colorectal cancers. The NCA NCORP proposes to address one of the most significant factors associated with this variance in cancer burden - limited access to optimal and cutting-edge prevention, cancer control, and cancer care delivery by increasing awareness and providing access to cancer clinical trials. LCCC’s Office of Health Disparities Research, represents the community outreach arm that is led by Dr. Adams-Campbell, that has established viable academic-community partnerships that enable the NCA NCORP to conduct clinical research in areas of prevention, control, screening, health variance, and cancer care delivery among the representative populations of interest. In light of an aging population and the increasing number of cancer survivors, this NCORP has the expertise and leadership as evident by demonstrable research in these areas that address cancer control and patient centered cancer care delivery. Furthermore, the ability to address cancer prevention and control among adolescents and young adults (AYA) is also a key strength of our team. The NCA NCORP will address the needs of our catchment area via cancer prevention, control, screening as well as treatment and imaging studies.
Publications
- Luskin MR, Yin J, Lozanski G, Curran E, Malnassy G, Mrózek K, Bloomfield CD, Cataland SR, Fulton N, Kolitz J, Laplant B, Kour O, Powell BL, Vij R, Wang ES, Grinblatt D, Stone RM, Uy GL, Larson RA, Stock W. Results of Cancer and Leukemia Group B 10102 (Alliance), a Phase 1/2 Study. Cancer. 2025 Feb 15;131(4):e35750. PMID: 39916320
- Ritchie EK, Klepin HD, Storrick E, Major B, Le-Rademacher J, Wadleigh M, Walker A, Larson RA, Roboz GJ. Geriatric assessment for older adults receiving less-intensive therapy for acute myeloid leukemia: report of CALGB 361101. Blood advances. 2022 Jun 28;6(12):3812-3820. PMID: 35420672
- Lai C, Lee M, Bobek O, Le-Rademacher J, Mandrekar S, Roboz GJ, Uy GL, Mandelblatt JS, Klepin HD. Deficit accumulation frailty index and treatment tolerability in AML: data from CALGB 11001 and 11002 (Alliance). Blood advances. 2025 Jan 28;9(2):398-401. PMID: 39602659
- Walter AW, Lee JW, Streck JM, Gareen IF, Herman BA, Kircher SM, Carlos RC, Kumar SK, Mayer IA, Saba NF, Fenske TS, Neal JW, Atkins MB, Hodi FS, Kyriakopoulos CE, Tempany-Afdhal CM, Shanafelt TD, Wagner LI, Land SR, Ostroff JS, Park ER. The effect of neighborhood socioeconomic disadvantage on smoking status, quit attempts, and receipt of cessation support among adults with cancer: Results from nine ECOG-ACRIN Cancer Research Group trials. Cancer. 2024 Feb 1;130(3):439-452. Epub 2023 Oct 5. PMID: 37795845
- Atkins MB, Lee SJ, Chmielowski B, Tarhini AA, Cohen GI, Truong TG, Moon HH, Davar D, O'Rourke M, Stephenson JJ, Curti BD, Urba WJ, Brell JM, Funchain P, Kendra KL, Ikeguchi AP, Jaslowski A, Bane CL, Taylor MA, Bajaj M, Conry RM, Ellis RJ, Logan TF, Laudi N, Sosman JA, Crockett DG, Pecora AL, Okazaki IJ, Reganti S, Chandra S, Guild S, Chen HX, Streicher HZ, Wolchok JD, Ribas A, Kirkwood JM. Combination Dabrafenib and Trametinib Versus Combination Nivolumab and Ipilimumab for Patients With Advanced BRAF-Mutant Melanoma: The DREAMseq Trial-ECOG-ACRIN EA6134. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2023 Jan 10;41(2):186-197. Epub 2022 Sep 27. PMID: 36166727
- Arai H, Yang Y, Baca Y, Millstein J, Denda T, Ou FS, Innocenti F, Takeda H, Kubota Y, Doi A, Horie Y, Umemoto K, Izawa N, Wang J, Battaglin F, Jayachandran P, Algaze S, Soni S, Zhang W, Goldberg RM, Hall MJ, Scott AJ, Hwang JJ, Lou E, Weinberg BA, Marshall J, Goel S, Xiu J, Michael Korn W, Venook AP, Sunakawa Y, Lenz HJ. Predictive value of CDC37 gene expression for targeted therapy in metastatic colorectal cancer. European journal of cancer (Oxford, England : 1990). 2024 Apr;201:113914. Epub 2024 Feb 10. PMID: 38359495
- Patel SP, Othus M, Chen Y, Wright GP Jr, Yost KJ, Hyngstrom JR, Hu-Lieskovan S, Lao CD, Fecher LA, Truong TG, Eisenstein JL, Chandra S, Sosman JA, Kendra KL, Wu RC, Devoe CE, Deutsch GB, Hegde A, Khalil M, Mangla A, Reese AM, Ross MI, Poklepovic AS, Phan GQ, Onitilo AA, Yasar DG, Powers BC, Doolittle GC, In GK, Kokot N, Gibney GT, Atkins MB, Shaheen M, Warneke JA, Ikeguchi A, Najera JE, Chmielowski B, Crompton JG, Floyd JD, Hsueh E, Margolin KA, Chow WA, Grossmann KF, Dietrich E, Prieto VG, Lowe MC, Buchbinder EI, Kirkwood JM, Korde L, Moon J, Sharon E, Sondak VK, Ribas A. Neoadjuvant-Adjuvant or Adjuvant-Only Pembrolizumab in Advanced Melanoma. The New England journal of medicine. 2023 Mar 2;388(9):813-823. PMID: 36856617
- Schneider BP, Zhao F, Ballinger TJ, Garcia SF, Shen F, Virani S, Cella D, Bales C, Jiang G, Hayes L, Miller N, Srinivasiah J, Stringer-Reasor EM, Chitalia A, Davis AA, Makower DF, Incorvati J, Simon MA, Mitchell EP, DeMichele A, Miller KD, Sparano JA, Wagner LI, Wolff AC. ECOG-ACRIN EAZ171: Prospective Validation Trial of Germline Predictors of Taxane-Induced Peripheral Neuropathy in Black Women With Early-Stage Breast Cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2024 Aug 20;42(24):2899-2907. Epub 2024 Jun 3. PMID: 38828938
- Streck JM, Lee JW, Walter AW, Rosen RL, Gareen IF, Kircher SM, Herman BA, Carlos RC, Kumar S, Mayer IA, Saba NF, Fenske TS, Neal JW, Atkins MB, Hodi FS, Kyriakopoulos CE, Tempany C, Shanafelt TD, Wagner LI, Land SR, Park ER, Ostroff JS. Cigarette and Alternative Tobacco Product Use among Adult Cancer Survivors Enrolled in 9 ECOG-ACRIN Clinical Trials. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2023 Nov 1;32(11):1552-1557. PMID: 37410096
- Holstein SA, Suman VJ, Owzar K, Santo K, Benson DM Jr, Shea TC, Martin T, Silverman M, Isola L, Vij R, Cheson BD, Linker C, Anderson KC, Richardson PG, McCarthy PL. Long-Term Follow-up of CALGB (Alliance) 100001: Autologous Followed by Nonmyeloablative Allogeneic Transplant for Multiple Myeloma. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2020 Aug;26(8):1414-1424. Epub 2020 Apr 20. PMID: 32325171
- Battaglin F, Baca Y, Millstein J, Yang Y, Xiu J, Arai H, Wang J, Ou FS, Innocenti F, Mumenthaler SM, Jayachandran P, Kawanishi N, Lenz A, Soni S, Algaze S, Zhang W, Khoukaz T, Roussos Torres E, Seeber A, Abraham JP, Lou E, Philip PA, Weinberg BA, Shields AF, Goldberg RM, Marshall JL, Venook AP, Korn WM, Lenz HJ. CCR5 and CCL5 gene expression in colorectal cancer: comprehensive profiling and clinical value. Journal for immunotherapy of cancer. 2024 Jan 11;12. (1). PMID: 38212126