Columbus Community Clinical Oncology Prg
United States
Columbus NCORP RFA-CA-18-016
Since its founding in 1983, the Columbus CCOP, now known as the Columbus NCORP, has been dedicated to providing high quality cancer care options in Central and Southeast Ohio as well as advancing cancer research through cancer research trials. The Columbus NCORP has grown in that time to encompass 20 affiliates and sub-affiliates, with 100 doctors serving as investigators. Over the six years comprising the next grant period, the NCORP plans to continue to grow in that capacity, improving its ability to participate in, assist with the design of, and successfully implement a wide range of cancer research trials, including treatment, cancer control, screening/surveillance, side effect prevention/management, and cancer care delivery research studies. In all areas the NCORP has been successful and plans to continue to grow in its ability to increase participation in cancer research in rural communities and Appalachia. Cancer care delivery research has been and continues to be a key component of this goal, as is continuing to improve care practices throughout the consortium. Close collaboration between NCORP affiliate institutions, non-oncology specialists, primary care physicians and community organizations is key to this goal. The Columbus NCORP plans to continue to pursue the cutting edge of cancer research through targeted and genomic therapies, while simultaneously seeking out and implementing trials that are directly applicable to those cancers with the highest incidence rate in our region: breast, colon and lung cancers. Over the past five years as an NCORP, and over the preceding 30 years as the Columbus CCOP, these areas have been a high priority and will continue to be as we aggressively pursue treatments that will advance the science of cancer care and best serve our local communities. The unique challenges facing Central and Southeast Ohio in these areas position the Columbus NCORP to make real and lasting contributions to cancer research, and the lessons learned here are widely applicable to regions across the country.
Publications
- Mayer IA, Zhao F, Arteaga CL, Symmans WF, Park BH, Burnette BL, Tevaarwerk AJ, Garcia SF, Smith KL, Makower DF, Block M, Morley KA, Jani CR, Mescher C, Dewani SJ, Tawfik B, Flaum LE, Mayer EL, Sikov WM, Rodler ET, Wagner LI, DeMichele AM, Sparano JA, Wolff AC, Miller KD. Reply to T. Shimoi et al and Y. Shimanuki et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2021 Nov 1;39(31):3522-3524. Epub 2021 Sep 23. PMID: 34554848
- Mayer IA, Zhao F, Arteaga CL, Symmans WF, Park BH, Burnette BL, Tevaarwerk AJ, Garcia SF, Smith KL, Makower DF, Block M, Morley KA, Jani CR, Mescher C, Dewani SJ, Tawfik B, Flaum LE, Mayer EL, Sikov WM, Rodler ET, Wagner LI, DeMichele AM, Sparano JA, Wolff AC, Miller KD. Randomized Phase III Postoperative Trial of Platinum-Based Chemotherapy Versus Capecitabine in Patients With Residual Triple-Negative Breast Cancer Following Neoadjuvant Chemotherapy: ECOG-ACRIN EA1131. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2021 Aug 10;39(23):2539-2551. Epub 2021 Jun 6. PMID: 34092112
- Mezzanotte-Sharpe J, ONeill A, Mayer IA, Arteaga CL, Yang XJ, Wagner LI, Cella D, Meropol NJ, Alpaugh RK, Saphner TJ, Swaney RE, Hoelzer KL, Gradishar WJ, Abramson VG, Sundaram PK, Jilani SZ, Perez EA, Lin NU, Jahanzeb M, Wolff AC, Sledge GW, Reid SA. A randomized phase III double-blind placebo-controlled trial of first line chemotherapy and trastuzumab with or without bevacizumab for patients with HER2/neu-positive metastatic breast cancer: a trial of the ECOG-ACRIN Cancer Research Group (E1105). Research square. 2024 Apr 29. PMID: 38746356
- Mezzanotte-Sharpe J, ONeill A, Mayer IA, Arteaga CL, Yang XJ, Wagner LI, Cella D, Meropol NJ, Alpaugh RK, Saphner TJ, Swaney RE, Hoelzer KL, Gradishar WJ, Abramson VG, Sundaram PK, Jilani SZ, Perez EA, Lin NU, Jahanzeb M, Wolff AC, Sledge GW, Reid SA. A randomized phase III double-blind placebo-controlled trial of first-line chemotherapy and trastuzumab with or without bevacizumab for patients with HER2/neu-positive metastatic breast cancer: a trial of the ECOG-ACRIN Cancer Research Group (E1105). Breast cancer research and treatment. 2024 Sep;207(2):275-282. Epub 2024 Jul 5. PMID: 38967884
- Smith KL, Zhao F, Mayer IA, Tevaarwerk AJ, Garcia SF, Arteaga CL, Symmans WF, Park BH, Burnette BL, Makower DF, Block M, Morley KA, Jani CR, Mescher C, Dewani SJ, Brown-Glaberman U, Flaum LE, Mayer EL, Sikov WM, Rodler ET, DeMichele AM, Sparano JA, Wolff AC, Miller KD, Wagner LI. Adjuvant platinum versus capecitabine for residual, invasive, triple-negative breast cancer: Patient-reported outcomes in ECOG-ACRIN EA1131. Cancer. 2024 May 15;130(10):1747-1757. Epub 2024 Jan 18. PMID: 38236702