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Cancer Immunoprevention Network (CIP-Net)

Wildtype and frameshift mutant Asxl1 mRNA detected by in situ hybridization using RNAScope technology in organoids derived from a mismatch repair-deficient mouse intestinal tumor.

The Cancer Immunoprevention Network (CIP-Net) supports the development of approaches that leverage the immune system to prevent cancers. Research in CIP-Net is advancing a deeper understanding of basic mechanisms of immunoprevention and promoting the discovery of novel immunoprevention strategies. Both the National Cancer Institute Division of Cancer Prevention and the Division of Cancer Biology support researchers in this network.

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About CIP-Net

CIP-Net supports projects from basic through translational preclinical research with an emphasis on exploring the biology of early malignancy and addressing the research gap between immunoprevention and immunotherapy.

The overall research objectives of the Network are to:

  • Discover novel immunoprevention pathways and targets
  • Elucidate immune responses to the earliest stages of carcinogenesis
  • Preclinical development and testing of interventions (agents/vaccines)
  • Investigate mechanisms of efficacy and potential side-effects of precision cancer prevention-interception strategies
  • Develop and optimize immunoprevention models
  • Define immune mechanisms of preventive cancer vaccines and immunomodulatory agents

Candidate agents and vaccines that emerge from CIP-Net research may move forward to the PREVENT program for further preclinical development towards clinical trials.

Grantee Details

PI Name Sort descending PI Organization Title Grant Number Program Official
Bedrosian, Isabelle

University Of Tx Md Anderson Can Ctr
United States

Chimeric RNA driven neopeptide vaccine for prevention of breast cancer in germline BRCA1/2 carriers 1UG3CA290454-01A1 Altaf Mohammed, Ph.D.
Demehri, Shadmehr

Massachusetts General Hospital
United States

Immunosurveillance of breast glands with oncogenic germline mutations 5UG3CA290300-02 Altaf Mohammed, Ph.D.
Dickinson, Sally E

University Of Arizona
United States

Investigating novel targets for topical immunoprevention of keratinocytic skin cancer 1UG3CA290443-01A1 Altaf Mohammed, Ph.D.
Hutson, Alan David

Roswell Park Cancer Institute Corp
United States

Cancer Immunoprevention Network (CIP-Net) Resource Coordinating Center 1U24CA305623-01 Altaf Mohammed, Ph.D.
NINA, BHARDWAJ,

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
United States

Immune determinants modulating cancer development in Lynch Syndrome 1UG3CA290517-01
Shirwan, Haval

University Of Missouri-Columbia
United States

Developing a novel agonist of CD137 for cancer immunoprevention 5UG3CA290305-02 Altaf Mohammed, Ph.D.

Program Contact(s)

Altaf Mohammed, Ph.D.
NCI DCP Chemopreventive Agent Development Research Group
Email: altaf.mohammed@nih.gov
Phone: 240-276-6082
Room: 5E554