Pre-Cancer Atlas (PCA)

A tumor (yellow) is shown in the background. Components within the microenvironment are overlaid on the tumor, including a dendritic cell (pink), a T-cell (blue), a fibroblast (purple and pink), a natural killer cell (dark blue), a regulatory t cell (aqua), blood vessels (red), a macrophage cell (red with a yellow center), and a myeloid cell (green).

The Pre-cancer Atlas (PCA) Research Centers are part of the Human Tumor Atlas Network (HTAN). HTAN, an NCI-collaborative program, is constructing multi-dimensional atlases of the cellular, morphological, molecular, and spatial features of human cancers and their surrounding microenvironments over time.

The atlases being created by HTAN describe important changes during cancer progression, such as the transition of precancers to malignant tumors, the evolution of metastatic cancer, and the development of treatment resistance.

HTAN is supported by the NCI Division of Cancer Prevention (DCP), NCI Division of Biology (DCB), the NCI Division of Cancer Treatment and Diagnosis (DCTD), and the NCI Center for Strategic Science Initiatives (CSSI).

About Pre-Cancer Atlas

The Pre-cancer Atlas (PCA) Research Centers, along with the Human Tumor Atlas (HTA) Research Centers and a Data Coordinating Center (DCC), make up HTAN. Each PCA Research Center will create a 2D/3D precancer atlas of a pre-cancerous lesion, focusing on how it changes into cancer.

PCA Research Centers have three major tasks:

Collecting, processing, and labeling biospecimens.
Studying the molecular, cellular, and spatial details of the lesions.
Analyzing and modeling the data.

PCA Research Centers will collaborate with other components of HTAN to make the data and analytical tools available to the research community.

Grantee Details

PI Name Sort descending	PI Organization	Title	Grant Number	Program Official
Zarrinpar, Amir	University Of California, San Diego United States	Engineering Native E. coli to Detect, Report, and Treat Colorectal Cancer	5U01CA265719-05	Guillermo Marquez, Ph.D.
Zeng, Melody Yue	Weill Medical Coll Of Cornell Univ United States	Dissecting the interplay between immunoglobulin G and the gut microbiome in cancer progression and metastasis	5R21CA270998-02	Young Kim, Ph.D.
Zhang, Zhen	Johns Hopkins University United States	A multidisciplinary BCC for ovarian cancer early detection: translating discoveries to clinical use with a by-design approach	5U2CCA271891-04	Christos Patriotis, Ph.D., M.Sc.
Zhao, Yingqi	Fred Hutchinson Cancer Center United States	Developing methods for advancing the early detection of pancreatic ductal adenocarcinoma leveraging electronic medical records data	1R01CA289668-01A1	Matthew Young, Ph.D.
Zhao, Hua	University Of Virginia United States	Homologous recombination repair capacity in peripheral blood lymphocytes as a breast cancer risk factor	4U01CA260731-04	Claire Zhu, Ph.D.
Zheng, Qin	Johns Hopkins University United States	Determining the function of medium to large diameter sensory neurons in paclitaxel-induced pain via large-scale in vivo DRG imaging	1R01CA291906-01A1	Rachel Altshuler, Ph.D.
Zheng, Yingye	Fred Hutchinson Cancer Center United States	Precompetitive Collaboration on Liquid Biopsy for Early Cancer Assessment: Data Management and Coordinating Unit	5U24CA288185-03	Guillermo Marquez, Ph.D.
Zheng, Qin	Johns Hopkins University United States	Determining the function of medium to large diameter sensory neurons in paclitaxel-induced pain via large-scale in vivo DRG imaging	1R01CA291906-01A1	Rachel Altshuler, Ph.D.
Zheng, Qin	Johns Hopkins University United States	Determining the function of medium to large diameter sensory neurons in paclitaxel-induced pain via large-scale in vivo DRG imaging	1R01CA291906-01A1	Rachel Altshuler, Ph.D.
Zheng, Yingye	Fred Hutchinson Cancer Center United States	The Early Detection Research Network: Data Management and Coordinating Center	5U24CA086368-25	Guillermo Marquez, Ph.D.
Zheng, Yingye	Fred Hutchinson Cancer Center United States	The Early Detection Research Network: Data Management and Coordinating Center	5U24CA086368-25	Guillermo Marquez, Ph.D.
Zhou, Xianghong Jasmine	University Of California Los Angeles United States	The UCLA Center in Early Detection of Liver Cancer	5U01CA230705-08	Sidney Fu, M.D.
Zhou, Xianghong Jasmine	University Of California Los Angeles United States	Multi-cancer early detection using cell-free DNA methylome analysis	5U01CA285010-03	Nicholas Hodges, Ph.D.
Zhou, Xianghong Jasmine	University Of California Los Angeles United States	Detecting and locating cancer for patients with CT-detected lung nodules	4R01CA264864-04	Guillermo Marquez, Ph.D.
Zhu, Yazhen	University Of California Los Angeles United States	Click Chemistry-Mediated Surface Protein Assay for Quantifying Subpopulations of Hepatocellular Carcinoma-associated Extracellular Vesicles	5R01CA277530-03	Matthew Young, Ph.D.

Pre-Cancer Atlas (PCA)

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About Pre-Cancer Atlas

Grantee Details