Liquid Biopsy Consortium

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Liquid Biopsy: A new, noninvasive technique that can detect disease biomarkers in blood, urine, and sputum.

In the era of personalized medicine, having minimally invasive methods to determine and follow the molecular composition and characterization of a patient’s tumor over time will help gain a broader understanding of the disease. One such approach is liquid biopsy : measurements to characterize the molecular level of the tumor and monitor genetic changes over time using repeat sampling of biofluids. Liquid biopsy generally refers to detecting and measuring circulating tumor cells (CTC), circulating tumor DNA (ctDNA), circulating exosomes and other analytes in body fluids, such as serum, plasma, urine, etc.

About the Liquid Biopsy Consortium

The Liquid Biopsy Consortium is an Academic/Industrial Partnership program designed to advance and validate Liquid Biopsy technologies specifically targeted for early stage cancer detection. The goal is to test body fluids such as blood, urine, saliva, stool, and sputum from patients suspected to have early stage cancer as well as those at high risk of developing cancer. The Liquid Biopsy Consortium is also working on methods to distinguish cancer from benign disease; or aggressive from indolent cancers. Projects from funded sites focus on the development of new tools/methods/assays and/or validations of existing technologies/methods involving the capture of DNA, RNA, or exosomes in circulating body fluids.

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Grantee Details

PI Name Sort descending	PI Organization	Title	Grant Number	Program Official
Zarrinpar, Amir	University Of California, San Diego United States	Engineering Native E. coli to Detect, Report, and Treat Colorectal Cancer	5U01CA265719-05	Guillermo Marquez, Ph.D.
Zeng, Melody Yue	Weill Medical Coll Of Cornell Univ United States	Dissecting the interplay between immunoglobulin G and the gut microbiome in cancer progression and metastasis	5R21CA270998-02	Young Kim, Ph.D.
Zhang, Zhen	Johns Hopkins University United States	A multidisciplinary BCC for ovarian cancer early detection: translating discoveries to clinical use with a by-design approach	5U2CCA271891-04	Christos Patriotis, Ph.D., M.Sc.
Zhao, Yingqi	Fred Hutchinson Cancer Center United States	Developing methods for advancing the early detection of pancreatic ductal adenocarcinoma leveraging electronic medical records data	1R01CA289668-01A1	Matthew Young, Ph.D.
Zhao, Hua	University Of Virginia United States	Homologous recombination repair capacity in peripheral blood lymphocytes as a breast cancer risk factor	4U01CA260731-04	Claire Zhu, Ph.D.
Zheng, Qin	Johns Hopkins University United States	Determining the function of medium to large diameter sensory neurons in paclitaxel-induced pain via large-scale in vivo DRG imaging	1R01CA291906-01A1	Rachel Altshuler, Ph.D.
Zheng, Yingye	Fred Hutchinson Cancer Center United States	Precompetitive Collaboration on Liquid Biopsy for Early Cancer Assessment: Data Management and Coordinating Unit	5U24CA288185-03	Guillermo Marquez, Ph.D.
Zheng, Qin	Johns Hopkins University United States	Determining the function of medium to large diameter sensory neurons in paclitaxel-induced pain via large-scale in vivo DRG imaging	1R01CA291906-01A1	Rachel Altshuler, Ph.D.
Zheng, Qin	Johns Hopkins University United States	Determining the function of medium to large diameter sensory neurons in paclitaxel-induced pain via large-scale in vivo DRG imaging	1R01CA291906-01A1	Rachel Altshuler, Ph.D.
Zheng, Yingye	Fred Hutchinson Cancer Center United States	The Early Detection Research Network: Data Management and Coordinating Center	5U24CA086368-25	Guillermo Marquez, Ph.D.
Zheng, Yingye	Fred Hutchinson Cancer Center United States	The Early Detection Research Network: Data Management and Coordinating Center	5U24CA086368-25	Guillermo Marquez, Ph.D.
Zhou, Xianghong Jasmine	University Of California Los Angeles United States	The UCLA Center in Early Detection of Liver Cancer	5U01CA230705-08	Sidney Fu, M.D.
Zhou, Xianghong Jasmine	University Of California Los Angeles United States	Multi-cancer early detection using cell-free DNA methylome analysis	5U01CA285010-03	Nicholas Hodges, Ph.D.
Zhou, Xianghong Jasmine	University Of California Los Angeles United States	Detecting and locating cancer for patients with CT-detected lung nodules	4R01CA264864-04	Guillermo Marquez, Ph.D.
Zhu, Yazhen	University Of California Los Angeles United States	Click Chemistry-Mediated Surface Protein Assay for Quantifying Subpopulations of Hepatocellular Carcinoma-associated Extracellular Vesicles	5R01CA277530-03	Matthew Young, Ph.D.

Program Contact(s)

Sudhir Srivastava, Ph.D., M.P.H.
Email: sudhir.srivastava@nih.gov

Christos Patriotis, Ph.D.
Email: christos.patriotis@nih.gov

Nicholas A. Hodges, Ph.D.
Email: nick.hodges@nih.gov

Guillermo Marquez, Ph.D.
Email: guillermo.marquez@nih.gov